4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane
methyl 4-hydroxycyclohexanecarboxylate
CAS: 17449-76-2
Molecular Formula: C8H14O3
4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane - Names and Identifiers
4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane - Physico-chemical Properties
| Molecular Formula | C8H14O3 |
| Molar Mass | 158.2 |
| Density | 1.121 |
| Boling Point | 233℃ |
| Flash Point | 94℃ |
| Vapor Presure | 8.14E-06mmHg at 25°C |
| pKa | 14.96±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.681 |
4-(Methoxycarbonyl)cyclohexan-1-ol, 1-Hydroxy-4-(methoxycarbonyl)cyclohexane - Reference Information
| Introduction | Methyl 4-hydroxycyclohexanecarboxylate is an organic intermediate, which can be obtained by esterification of 4-hydroxycyclohexanoic acid or obtained by reduction of methyl 4-oxocyclohexanecarboxylic acid. |
| Preparation | The methanol (30mL) suspension of stirred 4-hydroxycyclohexane-1-carboxylic acid (SM-1)(15g,104.1mmol) was dropwise added with sulfuric acid (0.9mL,15.6mmol) at room temperature in a nitrogen atmosphere and stirred at RT for 5 hours. After feedstock consumption (TLC monitoring), the reaction was quenched with water (50mL) and extracted with EtOAc (2x 100mL). The combined organic layer was washed with saturated NaHCO3 solution and saline solution. The organic layer is dried and concentrated under reduced pressure on Na2SO4 to provide methyl 4-hydroxycyclohexanarate (13.5g,82%), which is a liquid. |
Last Update：2024-04-10 22:29:15
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